Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …

Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis
inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified …

Our previous studies showed that ferroptosis plays an important role in the acute and
subacute stages of spinal cord injury. High intracellular iron levels and low glutathione …

The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary
mechanisms of injury. Though both mechanisms are involved in the neurological …

Glial cell types were classified less than 100 years ago by del Rio-Hortega. For instance, he
correctly surmised that microglia in pathologic central nervous system (CNS) were …

Fighting pathogens and maintaining tissue homeostasis are prerequisites for survival. Both
of these functions are upheld by the immune system, though the latter is often overlooked in …

Inflammation is a prominent feature of CNS injury that heavily influences neuronal survival,
yet the signals that initiate and control it remain poorly understood. Here we identify the …

Several distinct cell types in the adult central nervous system have been suggested to act as
stem or progenitor cells generating new cells under physiological or pathological conditions …

Spinal cord injury often results in permanent functional impairment. Neural stem cells
present in the adult spinal cord can be expanded in vitro and improve recovery when …