Harnessing transition metal scaffolds for targeted antibacterial therapy

C Weng, YLK Tan, WG Koh… - Angewandte Chemie …, 2023 - Wiley Online Library
Antimicrobial resistance, caused by persistent adaptation and growing resistance of
pathogenic bacteria to overprescribed antibiotics, poses one of the most serious and urgent …

[HTML][HTML] Ruthenium complexes in the fight against pathogenic microorganisms. An extensive review

AC Munteanu, V Uivarosi - Pharmaceutics, 2021 - mdpi.com
The widespread use of antibiotics has resulted in the emergence of drug-resistant
populations of microorganisms. Clearly, one can see the need to develop new, more …

Carbon monoxide signaling: examining its engagement with various molecular targets in the context of binding affinity, concentration, and biologic response

Z Yuan, LK De La Cruz, X Yang, B Wang - Pharmacological Reviews, 2022 - ASPET
Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …

Role of carbon monoxide in host–gut microbiome communication

CP Hopper, LK De La Cruz, KV Lyles… - Chemical …, 2020 - ACS Publications
Nature is full of examples of symbiotic relationships. The critical symbiotic relation between
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …

[HTML][HTML] A thiol-reactive Ru (II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3

HM Southam, TW Smith, RL Lyon, C Liao, CR Trevitt… - Redox biology, 2018 - Elsevier
Carbon monoxide (CO)-releasing molecules (CORMs), mostly metal carbonyl compounds,
are extensively used as experimental tools to deliver CO, a biological 'gasotransmitter', in …

Synergetic antimicrobial activity and mechanism of clotrimazole-linked CO-releasing molecules

SS Mendes, J Marques, E Mesterházy… - ACS bio & med …, 2022 - ACS Publications
Several metal-based carbon monoxide-releasing molecules (CORMs) are active CO donors
with established antibacterial activity. Among them, CORM conjugates with azole antibiotics …

Macromolecular agents with antimicrobial potentialities: A drive to combat antimicrobial resistance

M Bilal, T Rasheed, HMN Iqbal, H Hu, W Wang… - International Journal of …, 2017 - Elsevier
In recent years, the antimicrobial resistance (AMR) or multidrug resistance (MDR) has
become a serious health concern and major challenging issue, worldwide. After decades of …

[HTML][HTML] 'Carbon-monoxide-releasing molecule-2 (CORM-2)'is a misnomer: ruthenium toxicity, not CO release, accounts for its antimicrobial effects

HM Southam, MP Williamson, JA Chapman, RL Lyon… - Antioxidants, 2021 - mdpi.com
Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological
'gasotransmitter', in biological chemistry and biomedicine. CORMs kill bacteria in culture and …

The microbiology of ruthenium complexes

HM Southam, JA Butler, JA Chapman… - Advances in microbial …, 2017 - Elsevier
Ruthenium is seldom mentioned in microbiology texts, due to the fact that this metal has no
known, essential roles in biological systems, nor is it generally considered toxic. Since the …

Carbon monoxide: An emerging therapy for acute kidney injury

X Yang, M de Caestecker… - Medicinal research …, 2020 - Wiley Online Library
Treating acute kidney injury (AKI) represents an important unmet medical need both in terms
of the seriousness of this medical problem and the number of patients. There is also a large …