Turmeric has been in use since ancient times as a condiment and due to its medicinal
properties. Curcumin, the yellow coloring principle in turmeric, is a polyphenolic and a major …

Treatment after hypoxia—ischemia (HI) in immature rats with the N-methyl-d-aspartate
receptor (NMDAR) antagonist dizocilpine maleate (MK-801) reduces areas with high …

The objective of the present study was to determine the biochemical characteristics of Ca2+-
induced mitochondrial swelling (mitochondrial permeability transition; mPT) and cytochrome …

Cyclosporin A (CsA) reduces ischemic brain damage when administered in such a way that
its penetration across the blood–brain barrier is enhanced. Since only pretreatment has …

Mitochondria are central to brain cell response to ischemia, with critical roles in generation
of ATP, production of free radicals, and regulation of apoptotic cell death. Changes in the …

We show that mitochondrial function in the majority of hepatocytes isolated from old rats (24
mo) is significantly impaired. Mitochondrial membrane potential, cardiolipin levels …

Thrombolysis with intravenous alteplase (recombinant tissue-type plasminogen activator)
continues to be the sole recourse for acute ischemic stroke therapy, provided that patients …

Stroke is a major clinical problem, and acute pharmacological intervention with
neuroprotective agents has so far been unsuccessful. Recently, there has been …

Polyphenols are natural substances with variable phenolic structures and are elevated in
vegetables, fruits, grains, bark, roots, tea, and wine. There are over 8000 polyphenolic …

A hallmark of tissue injury in various models of ischemia/reperfusion (IR) is mitochondrial
dysfunction and the release of mitochondrial proapoptotic proteins leading to cell death …