[HTML][HTML] Persistent increases in cerebral lactate concentration after birth asphyxia

JD Hanrahan, IJ Cox, AD Edwards, FM Cowan… - Pediatric …, 1998 - nature.com
In this prospective study proton magnetic resonance spectroscopy (1 H MRS) was used to
test the hypothesis that lactate can be detected later than 1 mo after birth in the brains of …

The immunosuppressant drug FK506 ameliorates secondary mitochondrial dysfunction following transient focal cerebral ischemia in the rat

A Nakai, S Kuroda, T Kristián, BK Siesjö - Neurobiology of disease, 1997 - Elsevier
Recirculation following 2 h of focal ischemia due to transient middle cerebral artery (MCA)
occlusion has previously been found to be accompanied by an initial, partial recovery of the …

Mitochondrial glutathione: a modulator of brain cell death

NR Sims, M Nilsson, H Muyderman - Journal of bioenergetics and …, 2004 - Springer
The small fraction of glutathione in mitochondria in nonneural tissues is an important
contributor to cell survival under some conditions. However, there has been only limited …

Hemorrhagic transformation following ischemic stroke: significance, causes, and relationship to therapy and treatment

PA Lapchak - Current neurology and neuroscience reports, 2002 - Springer
Hemorrhagic transformation (HT) is a frequent consequence of ischemic stroke that
becomes more prevalent after thrombolytic therapy. Despite concerns about safety …

Mitochondrial mechanisms of neuroglobin's neuroprotection

Z Yu, JL Poppe, X Wang - Oxidative medicine and cellular …, 2013 - Wiley Online Library
Neuroglobin (Ngb) is an oxygen‐binding globin protein that has been demonstrated to be
neuroprotective against stroke and related neurological disorders. However, the underlying …

[HTML][HTML] The potential of mitochondrial modulation by neuroglobin in treatment of neurological disorders

AM Gorabi, S Aslani, GE Barreto, E Báez-Jurado… - Free Radical Biology …, 2021 - Elsevier
Neuroglobin is the third member of the globin family to be identified in 2000 in neurons of
both human and mouse nervous systems. Neuroglobin is an oxygen-binding globin found in …

Mitochondrial respiratory function and cell death in focal cerebral ischemia

MF Anderson, NR Sims - Journal of neurochemistry, 1999 - Wiley Online Library
Pyruvate‐supported oxygen uptake was determined as a measure of the functional capacity
of mitochondria obtained from rat brain during unilateral middle cerebral artery occlusion …

Effects of the Spin Trap Agent Disodium- [tert-butylimino)methyl]benzene-1,3-disulfonate N-Oxide (Generic NXY-059) on Intracerebral Hemorrhage in a Rabbit Large …

PA Lapchak, DM Araujo, D Song, J Wei, R Purdy… - Stroke, 2002 - Am Heart Assoc
Background and Purpose—It has been proposed that the novel spin trap agent disodium-
[(tert-butylimino) methyl] benzene-1, 3-disulfonate N-oxide (NXY-059) may be useful in the …

Involvement of reactive oxygen species in membrane phospholipid breakdown and energy perturbation after traumatic brain injury in the rat

A LEWÉN, L HILLERED - Journal of neurotrauma, 1998 - liebertpub.com
Interstitial glycerol may be a useful marker for posttraumatic and postischemic membrane
phospholipid (PL) breakdown. Degradation of membrane PLs is thought to be triggered by …

Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice

J Yang, H Ahn, M Chang, P Narasimhan… - Journal of …, 2013 - Wiley Online Library
Oxidative stress after stroke is associated with the inflammatory system activation in the
brain. The complement cascade, especially the degradation products of complement …