Background and Purpose Occlusion of the middle cerebral artery (MCAO) results in
bioenergetic failure in the densely ischemic core areas. During reperfusion, transient …

Recent investigations on transient focal cerebral ischemia suggested recovery of energy
metabolism during early reperfusion, but followed by secondary energy failure. As …

OBJECTIVE To evaluate interstitial glycerol as a marker of ischaemia by studying the
changes in glycerol in direct relation to changes in regional cerebral metabolic rate of …

Acute acoustic trauma (AAT) results in oxidative stress to the cochlea through
overproduction of cellular reactive oxygen, nitrogen, and other free radical species …

Edaravone has an inhibitory effect on lipid peroxidation by scavenging free radicals and
prevents vascular endothelial cell injury. We examined whether edaravone was effective on …

purpose. A prior study demonstrated that pretreatment with phenyl-N-tert-butylnitrone (PBN),
a synthetic antioxidant and free radical trapping agent, protects rats from light-induced …

Propofol has been shown to attenuate brain injury in experimental ischemia models, but few
studies have focused on the direct effect of propofol on mitochondrial dysfunction. In this …

The present experiments were undertaken to define changes in tissue calcium metabolism
in focal and perifocal (“penumbral”) tissues following 2 h of transient middle cerebral artery …

The term “stroke” is applied to a heterogeneous group of diseases caused by decreased
perfusion of the brain due to occlusion of the blood vessels supplying the brain or a …

In this study we explored if the secondary bioenergetic failure, which occurs a few hours
after recirculation, following transient middle cerebral artery occlusion (MCAO) in rats, is …