Different physiological adaptations for anoxia resistance have been described in the animal
kingdom. These adaptations are particularly important in organs that are highly susceptible …

Reactive oxygen species (ROS) are thought to contribute to the secondary injury process
after traumatic brain injury (TBI). ROS scavenging compounds have shown neuroprotective …

Both acute and chronic neurodegenerative diseases are frequently associated with
mitochondrial dysfunction as an essential component of mechanisms leading to brain …

Changes in apparent diffusion coefficients (ADC) were compared with alterations of
adenosine triphosphate (ATP) concentration and pH in different phases of transient focal …

Background and Purpose—It has been proposed that spin trap agents such as Nt-butyl-
phenylnitrone (PBN) may be useful as neuroprotective agents in the treatment of ischemia …

In previous studies, the authors showed that the nitrone radical scavenger α-phenyl-N-tert-
butyl nitrone (PBN) and its sulfo-derivative, 2-sulfo-phenyl-N-tert-butyl nitrone (S-PBN) …

White matter of the neonatal brain is highly sensitive to hypoxic–ischemic insult. The
susceptibility of premature oligodendrocytes (OLs) to free radicals (FRs) produced during …

Azulenyl nitrones are novel chain‐breaking antioxidants with low oxidation potentials and
high lipophilicity—properties favoring their efficacy as neuroprotectants. We tested the …

Rats were submitted to 10-min cardiac arrest, followed by resuscitation and survival for 1
day, 3 days or 1 week. Five regions of interest (CA1 and CA3 sector of hippocampus …

BACKGROUND: A noninvasive and effective route of cell delivery should be established to
yield maximal therapeutic effects for central nervous system (CNS) disorders. OBJECTIVE …