The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

This review is a historical account about purinergic signalling in the heart, for readers to see
how ideas and understanding have changed as new experimental results were published …

The endothelium plays a key role in blood vessel health. At the interface of the blood, it
releases several mediators that regulate local processes that protect against the …

Adequate oxygen delivery to the heart during stress is essential for sustaining cardiac
function. Acute increases in myocardial oxygen demand evoke coronary vasodilation and …

The local metabolic hypothesis proposes that myocardial oxygen tension determines the
degree of autoregulation by increasing the production of vasodilator metabolites as …

The coronary circulation has an innate ability to maintain constant blood flow over a wide
range of perfusion pressures. However, the mechanisms responsible for coronary …

Objectives Sodium-glucose cotransporter-2 inhibitor, canagliflozin, improves myocardial
perfusion to ischemic territory without accompanying changes in vascular density. We aimed …

INTRODUCTION: Off-target effects of novel antiplatelet agents due to their potential clinical
benefits are currently an area of intensive investigation. We aimed to compare the effects of …

The activation of purinergic receptors by nucleotides and/or nucleosides plays an important
role in the control of vascular function, including modulation of vascular smooth muscle …