Background Sickle cell disease (SCD) is a devastating, multisystemic disorder that affects
millions of people worldwide. The earliest clinical manifestations of SCD can affect infants as …

The transfusion of red blood cells (RBCs) is a crucial treatment for sickle cell disease (SCD).
While often beneficial, the frequent use of transfusions is associated with numerous …

Sickle cell disease (SCD), which affects approximately 100,000 individuals in the USA and
more than 3 million worldwide, is caused by mutations in the βb globin gene that result in …

We tested the hypothesis that fixed oral moderate-dose hydroxyurea (20 mg/kg per day) for
initial treatment of secondary stroke prevention results in an 80% relative risk reduction of …

This review had three aims: 1) describe the measures used to assess health-related quality
of life (HRQL) in pediatric patients diagnosed with sickle cell disease (SCD); 2) document …

Though rare, stroke in infants and children is an important cause of mortality and chronic
morbidity in the pediatric population. Neuroimaging advances and implementation of …

In children with sickle cell anemia (SCA) living in high-income set-tings, the routine use of
transcranial Doppler (TCD) measurements, coupled with monthly blood transfusion therapy …

Sickle cell disease is the most common inherited pathological haemoglobinopathy. Over the
past 30 years, disease-related morbidity and mortality have improved in high-income …

Transcranial Doppler (TCD) is a rapid and non-invasive diagnostic technique that can
provide real-time measurements of the relative changes in cerebral blood velocity (CBV) …

Abstract Purpose of Review To critically evaluate the recent literature on cognitive
impairment and headache. Recent Findings Neurocognitive symptoms are prevalent …