BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …

BACKGROUND Male infertility affects> 20 million men worldwide and represents a major
health concern. Although multifactorial, male infertility has a strong genetic basis which has …

Age at first sexual intercourse and age at first birth have implications for health and
evolutionary fitness. In this genome-wide association study (age at first sexual intercourse …

BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …

A pharmacologic approach to male contraception remains a longstanding challenge in
medicine. Toward this objective, we explored the spermatogenic effects of a selective small …

As a new widespread contaminant, nanoplastics (NPs) pose a potential risk to human
health. Nevertheless, the adverse effects of NPs on the male reproductive system are poorly …

During sexual reproduction, two haploid gametes fuse to form the zygote, and the acrosome
is essential to this fusion process (fertilization) in animals. The acrosome is a special kind of …

Mammalian fertilization comprises sperm migration through the female reproductive tract,
biochemical and morphological changes to sperm, and sperm-egg interaction in the oviduct …

The acrosome is a specialized organelle that covers the anterior part of the sperm nucleus
and plays an essential role in the process of fertilization. The molecular mechanism …

Infertility is a relatively common health condition, affecting nearly 7% of all couples.
Clinically, it is a highly heterogeneous pathology with a complex etiology that includes …