Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures
Absence seizures in children and teenagers are generally considered relatively benign
because of their non-convulsive nature and the large incidence of remittance in early …
because of their non-convulsive nature and the large incidence of remittance in early …
Current controversy: spikes, bursts, and synchrony in generalized absence epilepsy: unresolved questions regarding thalamocortical synchrony in absence epilepsy
J Huguenard - Epilepsy Currents, 2019 - journals.sagepub.com
Absence epilepsy is a disorder of thalamocortical networks. Animal models have provided
detailed information regarding the core cellular, synaptic, and network features that …
detailed information regarding the core cellular, synaptic, and network features that …
Astrocyte‐neuronal network interplay is disrupted in Alzheimer's disease mice
Alzheimer's disease (AD) is associated with senile plaques of beta‐amyloid (Aβ) that affect
the function of neurons and astrocytes. Brain activity results from the coordinated function of …
the function of neurons and astrocytes. Brain activity results from the coordinated function of …
[HTML][HTML] In Silico and In Vivo: Evaluating the Therapeutic Potential of Kaempferol, Quercetin, and Catechin to Treat Chronic Epilepsy in a Rat Model
Recently, alternative therapies are gaining popularity in the treatment of epilepsy. The
present study aimed to find out the antiepileptic potential of quercetin, catechin, and …
present study aimed to find out the antiepileptic potential of quercetin, catechin, and …
[HTML][HTML] EEG-fMRI in awake rat and whole-brain simulations show decreased brain responsiveness to sensory stimulations during absence seizures
P Stenroos, I Guillemain, F Tesler, O Montigon… - Elife, 2024 - elifesciences.org
In patients suffering absence epilepsy, recurring seizures can significantly decrease their
quality of life and lead to yet untreatable comorbidities. Absence seizures are characterized …
quality of life and lead to yet untreatable comorbidities. Absence seizures are characterized …
[HTML][HTML] Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene
The CACNA1A gene encodes the pore-forming α1 subunit of voltage-gated P/Q type Ca 2+
channels (Ca v 2.1). Mutations in this gene, among others, have been described in patients …
channels (Ca v 2.1). Mutations in this gene, among others, have been described in patients …
[HTML][HTML] Cognitive comorbidities of experimental absence seizures are independent of anxiety
M Neuparth-Sottomayor, CC Pina, TP Morais… - Neurobiology of …, 2023 - Elsevier
Typical absence seizures (ASs) are brief periods of lack of consciousness, associated with
2.5–4 Hz spike-wave discharges (SWDs) in the EEG, which are highly prevalent in children …
2.5–4 Hz spike-wave discharges (SWDs) in the EEG, which are highly prevalent in children …
[HTML][HTML] Chemogenetic activation of feed-forward inhibitory parvalbumin-expressing interneurons in the cortico-thalamocortical network during absence seizures
Parvalbumin-expressing (PV+) interneurons are a subset of GABAergic inhibitory
interneurons that mediate feed-forward inhibition (FFI) within the cortico-thalamocortical …
interneurons that mediate feed-forward inhibition (FFI) within the cortico-thalamocortical …
[HTML][HTML] From physiology to pathology of cortico-thalamo-cortical oscillations: astroglia as a target for further research
D Gobbo, A Scheller, F Kirchhoff - Frontiers in Neurology, 2021 - frontiersin.org
The electrographic hallmark of childhood absence epilepsy (CAE) and other idiopathic
forms of epilepsy are 2.5–4 Hz spike and wave discharges (SWDs) originating from …
forms of epilepsy are 2.5–4 Hz spike and wave discharges (SWDs) originating from …
[HTML][HTML] Altered GABAA Receptor Expression in the Primary Somatosensory Cortex of a Mouse Model of Genetic Absence Epilepsy
M Hassan, NK Adotevi, B Leitch - International Journal of Molecular …, 2022 - mdpi.com
Absence seizures are hyperexcitations within the cortico-thalamocortical (CTC) network,
however the underlying causative mechanisms at the cellular and molecular level are still …
however the underlying causative mechanisms at the cellular and molecular level are still …