[HTML][HTML] Inflammatory processes in alzheimer's disease—pathomechanism, diagnosis and treatment: a review

B Twarowski, M Herbet - International journal of molecular sciences, 2023 - mdpi.com
Alzheimer's disease is one of the most commonly diagnosed cases of senile dementia in the
world. It is an incurable process, most often leading to death. This disease is multifactorial …

[HTML][HTML] Melatonin and autophagy in aging-related neurodegenerative diseases

F Luo, AF Sandhu, W Rungratanawanich… - International Journal of …, 2020 - mdpi.com
With aging, the nervous system gradually undergoes degeneration. Increased oxidative
stress, endoplasmic reticulum stress, mitochondrial dysfunction, and cell death are …

[HTML][HTML] The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study

A Gharbi-Meliani, A Dugravot, S Sabia, M Regy… - Alzheimer's research & …, 2021 - Springer
Background Approximately 25% of the general population carries at least one ε4 allele of
the Apolipoprotein E (APOE ε4), the strongest genetic risk factor for late onset Alzheimer's …

aaUrgent Needs of Caregiving in Ageing Populations with Alzheimer's Disease and Other Chronic Conditions: Support Our Loved Ones

JW Culberson, J Kopel, U Sehar, PH Reddy - Ageing Research Reviews, 2023 - Elsevier
The ageing process begins at birth. It is a life-long process, and its exact origins are still
unknown. Several hypotheses attempt to describe the normal ageing process, including …

[HTML][HTML] MicroRNA alteration, application as biomarkers, and therapeutic approaches in neurodegenerative diseases

TPN Nguyen, M Kumar, E Fedele, G Bonanno… - International journal of …, 2022 - mdpi.com
MicroRNAs (miRNAs) are essential post-transcriptional gene regulators involved in various
neuronal and non-neuronal cell functions and play a key role in pathological conditions …

[HTML][HTML] Alzheimer's disease puzzle: delving into pathogenesis hypotheses

M Nasb, W Tao, N Chen - Aging and Disease, 2024 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by both
amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of …

[HTML][HTML] microRNA-based biomarkers in Alzheimer's disease (AD)

Y Zhao, V Jaber, PN Alexandrov, A Vergallo… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is a multifactorial, age-related neurological disease characterized
by complex pathophysiological dynamics taking place at multiple biological levels, including …

[HTML][HTML] Polydatin: pharmacological mechanisms, therapeutic targets, biological activities, and health benefits

A Karami, S Fakhri, L Kooshki, H Khan - Molecules, 2022 - mdpi.com
Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with
improved bioavailability. Polydatin possesses potential biological activities predominantly …

[HTML][HTML] C-Phycocyanin-derived phycocyanobilin as a potential nutraceutical approach for major neurodegenerative disorders and COVID-19-induced damage to the …

G Pentón-Rol, J Marín-Prida… - Current …, 2021 - ncbi.nlm.nih.gov
The edible cyanobacterium Spirulina platensis and its chief biliprotein C-Phycocyanin have
shown protective activity in animal models of diverse human health diseases, often reflecting …

Nanomedicine based strategies for oligonucleotide traversion across the blood–brain barrier

E Amulya, A Sikder, G Vambhurkar, S Shah… - Journal of Controlled …, 2023 - Elsevier
Neurological disorders are considered the most prominent cause of disability worldwide.
The major hurdle in the management of neurological disorders is the existence of the blood …