TRPV1 is a non-selective channel receptor widely expressed in skin tissues, including
keratinocytes, peripheral sensory nerve fibers and immune cells. It is activated by a variety of …

Capsaicin is a phytochemical derived from plants of the genus Capsicum and subject of
intensive phytochemical research due to its numerous physiological and therapeutical …

In recent years, sunscreens' adverse impacts on the environment and biology have gained
wide attention. The improvement of sunscreen safety has become one of the major priorities …

Psoriasis is a chronic inflammatory skin disease. Recently, lysophosphatidic acid
(LPA)/LPAR5 signaling has been reported to be involved in both NLRP3 inflammasome …

Pulsed dye laser (PDL) therapy can be effective in treating psoriasis, with a long duration of
remission. Although PDL therapy, albeit on a modest scale, is being used for decades now …

Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a Ca2+
permeable, non-selective cation channel that is found primarily in sensory nerve fibres …

Skin is a barrier to maintaining the stability of the human environment and preventing the
invasion of pathogens. When skin tissue is exposed to the external environment, it will …

Capsaicin, the most prominent pungent compound of chilli peppers, has been used in
traditional medicine systems for centuries; it already has a number of established clinical …

Glycyrol (GC) is one natural active product. Imiquimod-induced psoriasis-like Balb/c mouse
models were established. The model mice were intraperitoneally injected with cyclosporine …

Diseases such as cancer, neurological pathologies and chronic pain represent currently
unmet needs. The existing pharmacotherapeutic options available for treating these …