MicroRNAs are powerful gene expression regulators, but their corneal repertoire and
potential changes in corneal diseases remain unknown. Our purpose was to identify …

Astrocytes have been shown to protect neurons and increase their survival in many
pathological settings. Manipulating astrocyte functions is thus an important strategy to …

Reactive astrocytes have traditionally been viewed as a significant contributor to secondary
neuronal damage and repair inhibition after central nervous system (CNS) injury attributed …

Astrogliosis occurs at the lesion site within days to weeks after spinal cord injury (SCI) and
involves the proliferation and hypertrophy of astrocytes, leading to glia scar formation …

Early-onset, familial Alzheimer's disease (AD) is rare and may be attributed to disease-
causinq mutations. By contrast, late onset, sporadic (non-Mendelian) AD is far more …

Chronic demyelination is a hallmark of neurological disorders such as multiple sclerosis
(MS) and several leukodystrophies. In the central nervous system (CNS), remyelination is a …

Non-coding RNAs (ncRNAs) are a large cluster of RNAs that do not encode proteins, but
have multiple functions in diverse cellular processes. Mounting evidence indicates the …

Epilepsy affects around 50 million people worldwide, and in about 65% of patients, the
etiology of disease is unknown. MicroRNAs are small non-coding RNAs that have been …

Background Sevoflurane (sevo) has been reported to be an effective neuroprotective agent
in cerebral ischemia/reperfusion injury (CIRI). However, the precise molecular mechanism …

Recent studies have suggested that cortical astroglia play an important role in depressive-
like behaviors. Potential astroglial contributions have been proposed based on their known …