ABSTRACT A large body of evidence indicates modified expression of protein-coding genes
in response to different kinds of physical activity. Recent years have exposed another level …

Machado-Joseph disease (MJD) is a genetic neurodegenerative disease caused by an
expanded polyglutamine tract within the protein ataxin-3 (ATXN3). Despite current efforts …

The intestinal epithelium is a key physical interface that integrates dietary and microbial
signals to regulate nutrient uptake and mucosal immune cell function. The transcriptional …

Biliverdin is one of the three by-products of heme oxygenase (HO) activity, the others being
ferrous iron and carbon monoxide. Under physiological conditions, once formed in the cell …

Purpose: MicroRNAs are small, endogenous noncoding RNAs that modulate
posttranscriptional gene expression. Although the contribution of microRNAs to the …

Background: MicroRNAs (miRNAs) are important regulators of molecular pathways in
psychiatric disease. Here, we examine differential miRNAs expression in lymphoblastoid …

MicroRNAs (miRNAs) are small non-coding RNAs with a unique ability to regulate the
transcriptomic profile by binding to complementary regulatory RNA sequences. The ability of …

Decline in fluid abilities in normal aging is associated with increased white matter lesions,
measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs …

Background Controlling thrombin-driven microglial activation may serve as a therapeutic
target for intracerebral hemorrhage (ICH). Here, we investigated microRNA (miRNA)-based …

Recently, the microbiota-gut-brain axis (MGBA) has emerged as a target for therapeutic
innovation. Impairment of dynamic relationships within the MGBA promotes the pathological …