T Follicular Helper Cell Heterogeneity
T follicular helper (Tfh) cells specialize in helping B cells and are therefore critical
contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class …
contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class …
SREBP signaling is essential for effective B cell responses
Our previous study using systems vaccinology identified an association between the sterol
regulatory binding protein (SREBP) pathway and humoral immune response to vaccination …
regulatory binding protein (SREBP) pathway and humoral immune response to vaccination …
Regulation of follicular T helper cell differentiation in antitumor immunity
Y Hou, Y Cao, L Dong, Y Huang… - … Journal of Cancer, 2023 - Wiley Online Library
Follicular T helper (Tfh) cells are a subset of CD4+ T cells that play an important role in the
formation of germinal centers and the maturation and differentiation of affinity‐matured B …
formation of germinal centers and the maturation and differentiation of affinity‐matured B …
Recall of B cell memory depends on relative locations of prime and boost immunization
Immunization or microbial infection can establish long-term B cell memory not only
systemically but also locally. Evidence has suggested that local B cell memory contributes to …
systemically but also locally. Evidence has suggested that local B cell memory contributes to …
Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4+ T cell fate
Follicular helper T (Tfh) cells are essential for germinal center (GC) B cell responses.
However, it is not clear which PD-1+ CXCR5+ Bcl6+ CD4+ T cells will differentiate into PD …
However, it is not clear which PD-1+ CXCR5+ Bcl6+ CD4+ T cells will differentiate into PD …
Single-cell chemokine receptor profiles delineate the immune contexture of tertiary lymphoid structures in head and neck squamous cell carcinoma
B Zhang, H Li, YT Liu, D Xiong, L Zhang, ZJ Sun - Cancer Letters, 2023 - Elsevier
Tertiary lymphoid structures (TLSs) are organized aggregates of immune cells associated
with favourable prognosis and response to immunotherapy in cancer, but the immune …
with favourable prognosis and response to immunotherapy in cancer, but the immune …
Development of allergen-specific IgE in a food-allergy model requires precisely timed B cell stimulation and is inhibited by Fgl2
Immunoglobulin E (IgE) responses are a central feature of allergic disease. Using a well-
established food-allergy model in mice, we show that two sensitizations with cognate B cell …
established food-allergy model in mice, we show that two sensitizations with cognate B cell …
Tfh cells and the germinal center are required for memory B cell formation & humoral immunity after ChAdOx1 nCoV-19 vaccination
Emergence from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic has been facilitated by the rollout of effective vaccines. Successful vaccines …
pandemic has been facilitated by the rollout of effective vaccines. Successful vaccines …
Adaptive and innate immune responses in multiple sclerosis with anti-CD20 therapy: Gene expression and protein profiles
CC Fong, J Spencer, Q Howlett-Prieto, X Feng… - Frontiers in …, 2023 - frontiersin.org
Background Anti-CD20 is a highly effective therapy for multiple sclerosis (MS), a disease
with multiple abnormalities in function of B and T cells and innate immune cells. Anti-CD20 …
with multiple abnormalities in function of B and T cells and innate immune cells. Anti-CD20 …
Bob1 maintains T follicular helper cells for long-term humoral immunity
M Yanagi, I Ikegami, R Kamekura, T Sato… - Communications …, 2024 - nature.com
Humoral immunity is vital for host protection, yet aberrant antibody responses can trigger
harmful inflammation and immune-related disorders. T follicular helper (Tfh) cells, central to …
harmful inflammation and immune-related disorders. T follicular helper (Tfh) cells, central to …