An ideal animal model of atherosclerosis resembles human anatomy and pathophysiology
and has the potential to be used in medical and pharmaceutical research to obtain results …

Trimethylamine N-oxide (TMAO) is a biologically active molecule and is a putative promoter
of chronic diseases including atherosclerosis in humans. Host intestinal bacteria produce its …

Trimethylamine N‐oxide (TMAO) is a biologically active molecule generated by the gut
microbiota. Accumulating evidences have indicated a close association between high …

Trimethylamine-N-oxide (TMAO) is generated in a microbial-mammalian co-metabolic
pathway mainly from the digestion of meat-containing food and dietary quaternary amines …

NADPH oxidases (NOXs) are reactive oxygen species (ROS)-generating enzymes
implicated in the pathophysiology of vascular diseases such as hypertension and stroke …

Cardiovascular diseases are the first leading cause of death and morbidity in developed
countries. The use of animal models have contributed to increase our knowledge, providing …

Mouse strains are frequently used to model human disease states, to test the efficiency of
drugs and therapeutic principles. However, the direct translation of murine experimental …

Approximately one third of the human proteome contains metal cations, either in the form of
cofactors with catalytic functions or as structural support elements. 1, 2 To guarantee a …

Atherosclerotic plaques impair vascular function and can lead to arterial obstruction and
tissue ischaemia. Rupture of an atherosclerotic plaque within a coronary artery can result in …

Disordered lipid accumulation in the arterial wall is a hallmark of atherosclerosis. Previous
studies found that the expression of triggering receptor expressed on myeloid cells 2 …