In Diabetes, the chronic hyperglycemia and associated complications affecting peripheral
nerves are one of the most commonly occurring microvascular complications with an overall …

Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive
impairment and affects all levels of the brain's vasculature. Features include diverse …

Incubation of endothelial cells in vitro with high concentrations of glucose activates protein
kinase C (PKC) and increases nitric oxide synthase (NOS III) gene expression as well as …

The endothelial nitric oxide synthase (eNOS), the expression of which is regulated by a
range of transcriptional and posttranscriptional mechanisms, generates nitric oxide (NO) in …

Nitric oxide (NO) is synthesized by at least three distinct isoforms of NO synthase (NOS).
Their substrate and cofactor requirements are very similar. All three isoforms have some …

The activity of the endothelial nitric oxide synthase (eNOS) can be regulated independently
of an increase in Ca2+ by the phosphorylation of Ser1177 but results only in a low nitric …

Endothelial nitric-oxide synthase (eNOS) is an important regulatory enzyme in the
cardiovascular system catalyzing the production of NO from arginine. Multiple protein …

Consistent with its classification as a Ca2+/calmodulin-dependent enzyme the constitutive
endothelial nitric oxide (NO) synthase (eNOS) can be activated by receptor-dependent and …

Renal function is highly dependent on endothelium-derived nitric oxide (NO). Several renal
disorders have been linked to impaired NO bioavailability. The enzyme that is responsible …

Forty years of research into the function of l-glutamic acid as a neurotransmitter in the
vertebrate central nervous system (CNS) have uncovered a tremendous complexity in the …