Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis
Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only
24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and …
24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and …
Deciphering the evolution of flavin-dependent monooxygenase stereoselectivity using ancestral sequence reconstruction
CH Chiang, T Wymore… - Proceedings of the …, 2023 - National Acad Sciences
Controlling the selectivity of a reaction is critical for target-oriented synthesis. Accessing
complementary selectivity profiles enables divergent synthetic strategies, but is challenging …
complementary selectivity profiles enables divergent synthetic strategies, but is challenging …
Targeting the RNA-binding protein HuR in cancer
The RNA-binding protein human antigen R (HuR) is a well-established regulator of gene
expression at the posttranscriptional level. Its dysregulation has been implicated in various …
expression at the posttranscriptional level. Its dysregulation has been implicated in various …
RNA-binding proteins as regulators of migration, invasion and metastasis in oral squamous cell carcinoma
J Weiße, J Rosemann, V Krauspe, M Kappler… - International Journal of …, 2020 - mdpi.com
Nearly 7.5% of all human protein-coding genes have been assigned to the class of RNA-
binding proteins (RBPs), and over the past decade, RBPs have been increasingly …
binding proteins (RBPs), and over the past decade, RBPs have been increasingly …
Stereodivergent, chemoenzymatic synthesis of azaphilone natural products
JB Pyser, SA Baker Dockrey, AR Benítez… - Journal of the …, 2019 - ACS Publications
Selective access to a targeted isomer is often critical in the synthesis of biologically active
molecules. Whereas small-molecule reagents and catalysts often act with anticipated site …
molecules. Whereas small-molecule reagents and catalysts often act with anticipated site …
HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models
G Assoni, V La Pietra, R Digilio, C Ciani… - Advanced Drug Delivery …, 2022 - Elsevier
Abstract The Human antigen R (HuR) protein is an RNA-binding protein, ubiquitously
expressed in human tissues, that orchestrates target RNA maturation and processing both in …
expressed in human tissues, that orchestrates target RNA maturation and processing both in …
Human antigen R: A potential therapeutic target for liver diseases
R Liu, K Wu, Y Li, R Sun, X Li - Pharmacological Research, 2020 - Elsevier
Human antigen R (HuR), also known as HuA and embryonic lethal abnormal vision-like 1
(ELAVL1), is a ubiquitously expressed RNA binding protein and functions as an RNA …
(ELAVL1), is a ubiquitously expressed RNA binding protein and functions as an RNA …
HuR as therapeutic target in cancer: what the future holds
D Goutas, A Pergaris, C Giaginis… - Current Medicinal …, 2022 - ingentaconnect.com
ELAV-like protein 1 or HuR (human antigen R) is an RNA-binding protein that in humans is
encoded by the ELAVL1 gene, and one of its best functions is to stabilize mRNAs in order to …
encoded by the ELAVL1 gene, and one of its best functions is to stabilize mRNAs in order to …
The RNA binding protein HuR: a promising drug target for anticancer therapy
M Wu, CWS Tong, W Yan, KKW To… - Current cancer drug …, 2019 - ingentaconnect.com
The stability of mRNA is one of the key factors governing the regulation of eukaryotic gene
expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates …
expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates …
Drug delivery approaches for HuR-targeted therapy for lung cancer
Lung cancer (LC) is often diagnosed at an advanced stage and conventional treatments for
disease management have limitations associated with them. Novel therapeutic targets are …
disease management have limitations associated with them. Novel therapeutic targets are …