There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

Despite significant advances in its detection, understanding and management, atrial
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …

Cardiac alternans arises from dynamical instabilities in the electrical and calcium cycling
systems of the heart, and often precedes ventricular arrhythmias and sudden cardiac death …

The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Atrial fibrillation is a highly prevalent cardiac arrhythmia and the most important cause of
embolic stroke. Although genetic studies have identified an increasing assembly of AF …

Atrial fibrillation (AF) alters atrial cardiomyocyte (ACM) Ca 2+ handling, promoting ectopic
beat formation. We examined the effects of AF-associated remodeling on Ca 2+-related …

Atrial fibrillation is the most common arrhythmia in humans and is associated with high
morbidity, mortality and health-related expenses. Computational approaches have been …

Atrial fibrillation (AF) is characterized by disorganized rapid atrial electrical activity, which
leads to impaired atrial function, adverse hemodynamic effects, and increased …

AF is a progressive disease of the atria, involving complex mechanisms related to its
initiation, maintenance and progression. Computational modelling provides a framework for …