Objective Hypoxia-inducible factor 2α (HIF-2α), encoded by Epas1, causes osteoarthritic
cartilage destruction by regulating the expression of matrix-degrading enzymes. We …

The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases belonging to the
metzincin superfamily. There are at least 23 members of MMPs ever reported in human, and …

Osteoarthritis (OA) is increasingly recognised as a disease of diverse phenotypes with
variable clinical presentation, progression, and response to therapeutic intervention. This …

Age is the primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such as
destabilization of the medial meniscus (DMM) used for evaluating disease-modifying OA …

In this study, we examined the effects of overexpression of SIRT1 on IL‐1β‐induced gene
expression changes in human chondrocytes to explore a protective role of SIRT1 in human …

Objective To analyze a set of circulating microRNA (miRNA) in plasma from patients with
primary Osteoarthritis (OA) and describe the biological significance of altered miRNA in OA …

Joints that have degenerated as a result of aging or injury contain dead chondrocytes and
damaged cartilage. Some studies have suggested that chondrocyte death precedes …

Mechanical joint loading is an essential factor in joint homeostasis but it is also the most
important aetiological factor in the development of osteoarthritis (OA). Although OA has long …

Abstract Thrombospondin (TSP)-2, a matricellular glycoprotein of the TSP family, regulates
multiple biological functions, including proliferation, angiogenesis, cell adhesion, and …

Objective Joint injury-induced perturbations to the endocannabinoid system (ECS), a
regulator of both inflammation and nociception, remain largely uncharacterized. We …