The estrogen-related receptor (ERR) family of orphan nuclear receptor is composed of
ERRα, ERRβ, and ERRγ, which are known to regulate various isoform-specific functions …

Objectives Osteoarthritis (OA) is the most common joint disease; however, the indeterminate
nature of mechanisms by which OA develops has restrained advancement of therapeutic …

Objective Dkk is a family of canonical Wnt antagonists with 4 members (Dkk‐1, Dkk‐2, Dkk‐
3, and Dkk‐4). We undertook this study to explore the roles of Dkk‐1 and Dkk‐2 in …

Objective To determine the contribution of the gut microbiota to the development of injury-
induced osteoarthritis (OA). Design OA was induced using the destabilized medial meniscus …

Osteoarthritis (OA) is a disease characterized by cartilage damage and abnormal
remodeling of subchondral bone. Our previous study showed that in the early stage of OA …

Local inflammation in the joint is considered to contribute to osteoarthritis (OA) progression.
Here, we describe an immunomodulating nanoparticle for OA treatment. Intradermal …

Background Even though increasing evidences on miRNA involvement in human
pathological responses, the distinct roles and related mechanisms of miRNAs in the …

Objective Osteoarthritis (OA) is initiated by pathogenic factors produced by multiple stimuli,
including mechanical stress, metabolic stress, and/or inflammaging. This study was …

The Hippo/YAP signaling pathway is important for mediating organ size and tissue
homeostasis, but its role in osteoarthritis (OA) remains unclear. We aimed to investigate the …

Osteoarthritis (OA) treatment is limited by the lack of effective nonsurgical interventions to
slow disease progression. Here, we examined the contributions of the subchondral bone …