Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …

Objectives Synovium is acutely affected following joint trauma and contributes to post-
traumatic osteoarthritis (PTOA) progression. Little is known about discrete cell types and …

Osteoarthritis (OA) involves all the structures of the joint. How the disease is initiated and
what factors trigger the disease process remain unclear, although the mechanical …

Osteoarthritis (OA) is a whole joint disease, in which thinning and disappearance of cartilage
is a critical determinant in OA progression. The rupture of cartilage homeostasis whatever its …

Osteoarthritis (OA), primarily characterized by cartilage degeneration, is caused by an
imbalance between anabolic and catabolic factors. Here, we investigated the role of zinc (Zn …

Human cartilage is a complex tissue of matrix proteins that vary in amount and orientation
from superficial to deep layers and from loaded to unloaded zones. A major challenge to …

Arthritis is inflammation of the joints accompanied by osteochondral destruction. It can take
many forms, including osteoarthritis, rheumatoid arthritis, and psoriatic arthritis. These …

Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by cartilage loss
and accounts for a major source of pain and disability worldwide. However, effective …

Chondrocyte hypertrophy followed by cartilage matrix degradation and vascular invasion,
characterized by expression of type X collagen (COL10A1), matrix metalloproteinase-13 …

Osteoarthritis (OA) is the most common joint disease. Currently there are no effective
methods that simultaneously prevent joint degeneration and reduce pain. Although limited …