In adult healthy cartilage, chondrocytes are in a quiescent phase characterized by a fine
balance between anabolic and catabolic activities. In ageing, degenerative joint diseases …

Osteoarthritis (OA) is a highly prevalent disease affecting more than 20% of American adults.
Predispositions include joint injury, heredity, obesity, and aging. Biomechanical alterations …

The extracellular matrix (ECM) has long been regarded as a packing material; supporting
cells within the tissue and providing tensile strength and protection from mechanical stress …

Osteoarthritis is the most common degenerative musculoskeletal disease. In healthy
cartilage, a low turnover of extracellular matrix molecules occurs. Proper balance of anabolic …

Osteoarthritis (OA), long considered a primary disorder of articular cartilage, is commonly
associated with subchondral bone sclerosis. However, the cellular mechanisms responsible …

Animal models of osteoarthritis are extensively used for investigating disease pathways and
for preclinical testing of novel therapies. Their predictive utility, however, has often been …

Osteoarthritis is characterized by progressive breakdown of articular cartilage. This review
summarizes findings of the last year, which shed new light on mechanisms and factors …

Owing to the rapid aging of society, the numbers of patients with joint disease continue to
increase. Accordingly, a large number of patients require appropriate treatment for …

Osteoarthritis (OA) is a common degenerative condition that afflicts more than 70% of the
population between 55 and 77 years of age. Although its prevalence is rising globally with …

Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized
by the progressive destruction of articular cartilage, synovial inflammation, changes in …