The composition and cellular organization of human adult articular cartilage are complex
with qualitative and quantitative differences in matrix constituents ranging from the …

Objective Hypoxia‐inducible factor 2α (HIF‐2α)(encoded by Epas1) causes osteoarthritic
(OA) cartilage destruction by regulating the expression of catabolic factor genes. We …

Gut microbiota dysbiosis has been studied under the pathological conditions of osteoarthritis
(OA). However, the effect of antibiotic-induced gut flora dysbiosis on OA remains …

The role of DNA methylation in the regulation of catabolic genes such as MMP13 and IL1B,
which have sparse CpG islands, is poorly understood in the context of musculoskeletal …

Rheumatoid arthritis (RA) is a chronic, autoimmune pathology characterized by persistent
synovial inflammation and gradually advancing bone destruction. Matrix metalloproteinases …

Objective Mechanical loading through a mechano‐adaptive response modifies articular
cartilage structure and contributes to osteoarthritis (OA). However, the specific mechanical …

There is no disease-modifying therapy for osteoarthritis, a degenerative joint disease that is
projected to afflict more than 67 million individuals in the United States alone by 2030 …

OBJECTIVE: The objectives of this study were to (1) determine the correlation between
osteoarthritis (OA) and Indian hedgehog (Ihh) expression, and (2) establish the effects of Ihh …

Osteoarthritis (OA) is a multifactorial disease subject to the effects of many genes and
environmental factors. Alterations in the normal pattern of chondrocyte gene control in …

Most of our bones form through the process of endochondral ossification, which is tightly
regulated by the activity of the cartilage growth plate. Chondrocyte maturation through the …