Osteoarthritis (OA) is a chronic degenerative joint disorder characterized by destruction of
the articular cartilage, subchondral bone alterations and synovitis. Current treatments are …

Summary Objective/Method Aggrecanase activity, most notably ADAMTS-5, is implicated in
pathogenic cartilage degradation. Selective monoclonal antibodies (mAbs) to both ADAMTS …

Objective To explore the involvement of protease‐activated receptor 1 (PAR‐1) and PAR‐2
in the pathologic processes of osteoarthritis (OA) and to identify the cells/tissues primarily …

Apoptosis of articular chondrocytes is associated with the pathogenesis of osteoarthritis
(OA). Recently, we demonstrated that hypoxia-inducible factor (HIF)-2α, encoded by Epas1 …

Osteoarthritis (OA) is a common chronic inflammatory disease in the joints. It is one of the
leading causes of disability with increasing morbidity, which has become one of the serious …

Osteoarthritis (OA) is one of the most widespread degenerative joint diseases affecting the
elderly. Research into the regulatory mechanisms underlying the pathogenesis of OA is …

Introduction Increased expression of aggrecanase-1 (ADAMTS-4) has emerged as an
important factor in osteoarthritis (OA) and other joint diseases. This study aimed to determine …

Inflammatory diseases decrease the extracellular environmental pH. However, whether
proton-activated G protein-coupled receptors (GPCRs) can regulate the development of …

Piezo proteins are mechanically activated ion channels, which are required for
mechanosensing functions in a variety of cell types. While we and others have previously …

Animal models have been used for a number of decades to study arthritis and have
contributed greatly to unravelling mechanisms of pathogenesis and validating new targets …