Molecular dynamics simulations of membranes and membrane proteins serve as
computational microscopes, revealing coordinated events at the membrane interface. As G …

Pair bonds represent some of the strongest attachments we form as humans. These
relationships positively modulate health and well-being. Conversely, the loss of a spouse is …

Neuropeptides and peptide hormones are ancient, widespread signaling molecules that
underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly …

Many different intrinsically disordered proteins and proteins with intrinsically disordered
regions are associated with neurodegenerative diseases. These types of proteins including …

Background Genotypes are strongly associated with disease phenotypes, particularly in
brain disorders. However, the molecular and cellular mechanisms behind this association …

Experimental evidence indicates that cannabidiol (CBD) induces anxiolytic and antiepileptic
effects through the activation of 5-HT1A receptors. These receptors are coupled to Gi/o …

Biased G protein–coupled receptor (GPCR) ligands, which preferentially activate G protein
or β-arrestin signaling pathways, are leading to the development of drugs with superior …

Purpose Neuroinflammation is an essential causative factor in the pathogenesis and
progression of cognitive impairment. The present study aims to evaluate the critical role of …

G protein-coupled receptors (GPCRs) are successful druggable targets, making up around
35% of all FDA-approved medications. However, a large number of receptors remain …

Antidepressants target a variety of proteins in the central nervous system (CNS), the most
important belonging to the family of G-protein coupled receptors and the family of …