CHARMM-GUI Membrane Builder: Past, Current, and Future Developments and Applications
Molecular dynamics simulations of membranes and membrane proteins serve as
computational microscopes, revealing coordinated events at the membrane interface. As G …
computational microscopes, revealing coordinated events at the membrane interface. As G …
Oxytocin, dopamine, and opioid interactions underlying pair bonding: highlighting a potential role for microglia
MK Loth, ZR Donaldson - Endocrinology, 2021 - academic.oup.com
Pair bonds represent some of the strongest attachments we form as humans. These
relationships positively modulate health and well-being. Conversely, the loss of a spouse is …
relationships positively modulate health and well-being. Conversely, the loss of a spouse is …
[HTML][HTML] System-wide mapping of peptide-GPCR interactions in C. elegans
I Beets, S Zels, E Vandewyer, J Demeulemeester… - Cell reports, 2023 - cell.com
Neuropeptides and peptide hormones are ancient, widespread signaling molecules that
underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly …
underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly …
Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases
O Coskuner-Weber, O Mirzanli, VN Uversky - Biophysical Reviews, 2022 - Springer
Many different intrinsically disordered proteins and proteins with intrinsically disordered
regions are associated with neurodegenerative diseases. These types of proteins including …
regions are associated with neurodegenerative diseases. These types of proteins including …
[HTML][HTML] DeepGAMI: deep biologically guided auxiliary learning for multimodal integration and imputation to improve genotype–phenotype prediction
Background Genotypes are strongly associated with disease phenotypes, particularly in
brain disorders. However, the molecular and cellular mechanisms behind this association …
brain disorders. However, the molecular and cellular mechanisms behind this association …
[HTML][HTML] Cannabidiol Acts at 5-HT1A Receptors in the Human Brain: Relevance for Treating Temporal Lobe Epilepsy
C Martínez-Aguirre, F Carmona-Cruz… - Frontiers in behavioral …, 2020 - frontiersin.org
Experimental evidence indicates that cannabidiol (CBD) induces anxiolytic and antiepileptic
effects through the activation of 5-HT1A receptors. These receptors are coupled to Gi/o …
effects through the activation of 5-HT1A receptors. These receptors are coupled to Gi/o …
G protein–biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model
Y Huang, T Rafael Guimarães… - Proceedings of the …, 2022 - National Acad Sciences
Biased G protein–coupled receptor (GPCR) ligands, which preferentially activate G protein
or β-arrestin signaling pathways, are leading to the development of drugs with superior …
or β-arrestin signaling pathways, are leading to the development of drugs with superior …
MicroRNA-138-5p regulates hippocampal neuroinflammation and cognitive impairment by NLRP3/caspase-1 signaling pathway in rats
X Feng, J Hu, F Zhan, D Luo, F Hua… - Journal of inflammation …, 2021 - Taylor & Francis
Purpose Neuroinflammation is an essential causative factor in the pathogenesis and
progression of cognitive impairment. The present study aims to evaluate the critical role of …
progression of cognitive impairment. The present study aims to evaluate the critical role of …
Orphan G protein-coupled receptor GPR37 as an emerging therapeutic target
AA Bolinger, A Frazier, JH La, JA Allen… - ACS chemical …, 2023 - ACS Publications
G protein-coupled receptors (GPCRs) are successful druggable targets, making up around
35% of all FDA-approved medications. However, a large number of receptors remain …
35% of all FDA-approved medications. However, a large number of receptors remain …
[HTML][HTML] Novel molecular targets of antidepressants
M Jarończyk, J Walory - Molecules, 2022 - mdpi.com
Antidepressants target a variety of proteins in the central nervous system (CNS), the most
important belonging to the family of G-protein coupled receptors and the family of …
important belonging to the family of G-protein coupled receptors and the family of …