Type 1 fimbriae are the most commonly expressed virulence factor on uropathogenic
Escherichia coli. In addition to promoting avid bacterial adherence to the uroepithelium and …

Mucosal pathogens differ from normal flora constituents in that they provoke a host response
that upsets mucosal integrity. We investigated whether the elaboration of discrete adherence …

During bacterial infections at mucosal sites, neutrophils migrate to the mucosa and cross the
epithelial barrier. We have examined neutrophil migration across Escherichia coli-stimulated …

Bacterial adhesion to the bladder mucosa is a critical step for the establishment of
Escherichia coli bacteriuria. The P-fimbriae, encoded by the pap gene cluster, are …

Release of urokinase plasminogen activator receptor during urosepsis and endotoxemia.
Background The urokinase receptor (uPAR; CD87) is a multifunctional molecule involved in …

Boosting innate immunity represents an important therapeutic alternative to antibiotics.
However, the molecular selectivity of this approach is a major concern because innate …

Uropathogenic E. coli (UPEC) causes the majority of urinary tract infections (UTIs), which are
a major global public health concern. UPEC uses numerous mechanisms to subvert the …

Periodontitis is the inflammatory response in periodontal tissues elicited by bacterial
colonization in periodontal pockets. In this response, pocket epithelial cells are the first cells …

Purpose: To examine the cytokine profile of epithelial cells lining the human urinary tract
with the aim of differentiating between the constitutive and disease-related cytokine …

PURPOSE: Recurrent upper urinary tract infection is a common complication of
vesicoureteral reflux that often leads to irreversible renal scarring. In our previous study of a …