Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity

H Tilg, TE Adolph, M Dudek, P Knolle - Nature metabolism, 2021 - nature.com
Non-alcoholic fatty liver disease (NAFLD) has emerged pandemically across the globe and
particularly affects patients with obesity and type 2 diabetes. NAFLD is a complex systemic …

Genetic and biological hallmarks of colorectal cancer

J Li, X Ma, D Chakravarti, S Shalapour… - Genes & …, 2021 - genesdev.cshlp.org
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Calprotectin: from biomarker to biological function

A Jukic, L Bakiri, EF Wagner, H Tilg, TE Adolph - Gut, 2021 - gut.bmj.com
The incidence of inflammatory bowel diseases (IBD) emerged with Westernisation of dietary
habits worldwide. Crohn's disease and ulcerative colitis are chronic debilitating conditions …

Gut microbiota interact with the brain through systemic chronic inflammation: implications on neuroinflammation, neurodegeneration, and aging

Y Mou, Y Du, L Zhou, J Yue, X Hu, Y Liu… - Frontiers in …, 2022 - frontiersin.org
It has been noticed in recent years that the unfavorable effects of the gut microbiota could
exhaust host vigor and life, yet knowledge and theory are just beginning to be established …

[HTML][HTML] Chronic inflammation in the etiology of disease across the life span

D Furman, J Campisi, E Verdin, P Carrera-Bastos… - Nature medicine, 2019 - nature.com
Although intermittent increases in inflammation are critical for survival during physical injury
and infection, recent research has revealed that certain social, environmental and lifestyle …

Hemicyanine‐based near‐infrared activatable probes for imaging and diagnosis of diseases

Z Zeng, SS Liew, X Wei, K Pu - Angewandte Chemie, 2021 - Wiley Online Library
Molecular activatable probes with near‐infrared (NIR) fluorescence play a critical role in in
vivo imaging of biomarkers for drug screening and disease diagnosis. With structural …

Diversity, mechanisms, and significance of macrophage plasticity

M Locati, G Curtale, A Mantovani - Annual Review of Pathology …, 2020 - annualreviews.org
Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …

The intestinal microbiota fuelling metabolic inflammation

H Tilg, N Zmora, TE Adolph, E Elinav - Nature Reviews Immunology, 2020 - nature.com
Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …

Multifunctional role of S100 protein family in the immune system: an update

P Singh, SA Ali - Cells, 2022 - mdpi.com
S100 is a broad subfamily of low-molecular weight calcium-binding proteins (9–14 kDa) with
structural similarity and functional discrepancy. It is required for inflammation and cellular …

The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

C d'Enfert, AK Kaune, LR Alaban… - FEMS microbiology …, 2021 - academic.oup.com
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …