[HTML][HTML] Seizure-induced hilar ectopic granule cells in the adult dentate gyrus

Y Kasahara, H Nakashima, K Nakashima - Frontiers in Neuroscience, 2023 - frontiersin.org
Epilepsy is a chronic neurological disorder characterized by hypersynchronous
spontaneous recurrent seizures, and affects approximately 50 million people worldwide …

[HTML][HTML] Microglial displacement of GABAergic synapses is a protective event during complex febrile seizures

Y Wan, B Feng, Y You, J Yu, C Xu, H Dai, BD Trapp… - Cell Reports, 2020 - cell.com
Complex febrile seizures (FSs) lead to a high risk of intractable temporal lobe epilepsy
during adulthood, yet the pathological process of complex FSs is largely unknown. Here, we …

Effects of bumetanide on neonatal seizures: A systematic review of animal and human studies

S Rao, A Farhat, A Rakshasbhuvankar… - … : European Journal of …, 2023 - Elsevier
Background Bumetanide, an inhibitor of the sodium-potassium-chloride cotransporter-1, has
been suggested as an adjunct to phenobarbital for treating neonatal seizures. Methods A …

[HTML][HTML] Identification of an exporter that regulates vitamin C supply from blood to the brain

H Miyata, Y Toyoda, T Takada, T Hiragi, Y Kubota… - IScience, 2022 - cell.com
Vitamin C (VC) distribution in our body requires VC transporters. However, mammalian VC
exporters are yet to be identified. Herein, to unravel this long-standing mystery, we focused …

Inflammation as a target for the treatment of fever-associated epilepsy in zebrafish larvae

W Liang, J Wang, J Sui, F Yun, Y Shen, J Zhou… - International …, 2023 - Elsevier
Inflammation is considered to be involved in epileptogenesis. However, the relationship
between fever and inflammation as well as the mechanisms of fever in the occurrence and …

Microglia induce auditory dysfunction after status epilepticus in mice

T Araki, T Hiragi, N Kuga, C Luo, M Andoh, K Sugao… - Glia, 2024 - Wiley Online Library
Auditory dysfunction and increased neuronal activity in the auditory pathways have been
reported in patients with temporal lobe epilepsy, but the cellular mechanisms involved are …

[HTML][HTML] Suppressive effects of a transient receptor potential melastatin 8 (TRPM8) agonist on hyperthermia-induced febrile seizures in infant mice

H Moriyama, S Nomura, H Imoto, F Oka… - Frontiers in …, 2023 - frontiersin.org
Background: Febrile seizures (FSs) are the most frequent type of seizures in infancy and
childhood. Epileptiform discharges (EDs) on electroencephalogram at the time of first FS …

[HTML][HTML] Collection of biochemical samples with brain-wide electrophysiological recordings from a freely moving rodent

D Konno, R Nakayama, M Tsunoda, T Funatsu… - Journal of …, 2019 - Elsevier
Bridging accumulating insights from microscopic and macroscopic studies in neuroscience
research requires monitoring of neuronal population dynamics and quantifying specific …

Augmented impulsive behavior in febrile seizure-induced mice

CG Remonde, EL Gonzales, KJ Adil, SJ Jeon… - Toxicological …, 2023 - Springer
Febrile seizure (FS) is one of the most prevalent etiological events in childhood affecting 2–
5% of children from 3 months to 5 years old. Debates on whether neurodevelopmental …

Staving Off the Heat With Microglia

GF Buchanan - Epilepsy currents, 2021 - journals.sagepub.com
Microglial Displacement of GABAergic Synapses Is a Protective Event During Complex
Febrile Seizures Wan Y, Feng B, You Y, et al. Cell Reports. 2020; 33 (5): 108346. doi …