Androgens are key for pubertal development of the mammalian testis, a phenomenon that is
tightly linked to Sertoli cell maturation. In this review, we discuss how androgen signaling …

Spermatogenesis is a complex process occurring in mammalian testes, and constant sperm
production depends on the exact regulation of the microenvironment in the testes. Many …

Nickel (Ni) is an essential common environmental contaminant, it is hazardous to male
reproduction, but the precise mechanisms are still unknown. Blood-testis barrier (BTB), an …

Cadmium is a common environmental pollutant in daily life, the toxic mechanisms of chronic
cadmium exposure on the testes have not been fully elucidated. This study aimed to explore …

The potential impact of the combination of a high‐fat diet (HFD) and polystyrene
nanoplastics (PS‐NPs) on fertility cannot be ignored, especially when the fertility rate is …

Background RNA N 6-methyladenosine (m6A) is involved in mammalian spermatogenesis.
In both germ cells and Leydig cells, ALKBH5 regulates spermatogenesis and androgen …

Testicular invasion and persistence are features of Zika virus (ZIKV), but their mechanisms
are still unknown. Here, we showed that S100A4+ macrophages, a myeloid macrophage …

Sertoli cells (SCs) support and nourish germ cells (GCs) through their crosstalk during
spermatogenesis. However, the underlying epigenetic mechanism that ensures SCs' …

Background This study aimed to comprehensively evaluate the toxicity exerted by zinc oxide
nanoparticles (ZnO NPs) on rat testis and its effects on fertility and progeny development …

Azithromycin is a commonly used antibiotic during pregnancy, but some studies have
suggested its potential developmental toxicity. Currently, the effects and mechanisms of …