Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …

The predominant risk factor for the progression of glaucoma is an increase in IOP, mediated
via a reduction in aqueous outflow through the conventional (trabecular meshwork and …

Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …

Purpose.: Pathology in the primary drainage pathway for aqueous humor in the eye is
responsible for ocular hypertension, the only treatable risk factor in patients with glaucoma …

Elevated intraocular pressure (IOP) is the most prevalent risk factor for glaucoma. All
treatments, whether surgical or pharmaceutical, are aimed at lowering IOP. Prostaglandin …

Primary open-angle glaucoma (POAG) is a genetically complex common disease
characterized by progressive optic nerve degeneration that results in irreversible blindness …

Nitric oxide (NO) is a promising approach for treating ocular hypertension and glaucoma.
However, its clinical application is limited by its uncontrollable release and the unwanted …

Prostaglandin (PG) receptors represent important druggable targets due to the many diverse
actions of PGs in the body. From an ocular perspective, the discovery, development, and …

The eye is continuously exposed to solar UV radiation and pollutants, making it prone to
oxidative attacks. In fact, oxidative damage is a major cause of age‐related ocular diseases …

Glaucoma is a prevalent optic neuropathy characterized by the progressive dysfunction and
loss of retinal ganglion cells (RGCs) and their optic nerve axons, which leads to irreversible …