T cell senescence has been recognized to play an immunosuppressive role in the aging
population and cancer patients. Strategies dedicated to preventing or reversing replicative …

T cell receptor-engineered T cell (TCR-T) therapy is free from the limit of surface antigen
expression of the target cells, which is a potential cellular immunotherapy for cancer …

Since its discovery in 2012, CRISPR Cas9 has been tried as a direct treatment approach to
correct the causative gene mutation and establish animal models in neurodegenerative …

Introduction: Umbilical cord blood (UCB), previously seen as medical waste, is increasingly
recognized as a valuable source of cells for therapeutic use. The best-known application is …

Mesenchymal stem cells (MSCs) are of particular interest for the treatment of immune-
related diseases due to their immunosuppressive capacity. Here, we show that Small MSCs …

Aims: Cellular senescence and its secretory phenotype (senescence-associated secretory
phenotype [SASP]) develop after long-term expansion of mesenchymal stromal cells …

In vitro manipulation of human stem cells is a critical process in regenerative medicine and
cellular therapies. Strategies and methods to maintain stem cells and direct them into …

Methods The soluble RAGE (sRAGE) secreting Umbilical Cord Blood—derived
Mesenchymal Stem Cell (UCB-MSC) was generated by gene editing method using …

Background Cell-based therapies are promising for tolerance induction in bone marrow
(BM), solid organs, and vascularized composite allotransplantation (VCA). The toxicity of …

Rationale: Mesenchymal stem cell (MSC) therapy may be a novel approach to improve
interstitial cystitis/bladder pain syndrome (IC/BPS), an intractable disease characterized by …