Malaria is a major global health problem that causes significant mortality and morbidity
annually. The therapeutic options are scarce and massively challenged by the emergence of …

Enhancing the geographic coverage of surveillance for resistance will be key to ensure
prompt detection of emerging resistance in order to implement effective countermeasures …

Antimalarial drug resistance has thrown a spanner in the works of malaria elimination. New
drugs are required for ancillary support of existing malaria control efforts. Plasmodium …

Mechanisms of action (MoAs) have been elusive for most antimalarial drugs in clinical use.
Decreasing responsiveness to antimalarial treatments stresses the need for a better …

The use of artemisinin-based combination therapies (ACTs), which combine an artemisinin
derivative with a partner drug, in the treatment of uncomplicated malaria has largely been …

The complement system is an essential player in innate and adaptive immunity. It consists of
three pathways (alternative, classical, and lectin) that initiate either spontaneously …

Summary Background Potentially untreatable Plasmodium falciparum malaria threatens the
Greater Mekong subregion. A previous series of pilot projects in Myanmar, Laos, Cambodia …

Malaria—a parasite vector-borne disease—is a global health problem, and Plasmodium
falciparum has proven to be the deadliest among Plasmodium spp., which causes malaria in …

The global challenge to the treatment of malaria is mainly the occurrence of resistance of
malaria parasites to conventionally used antimalarials. Artesunate, a semisynthetic …

Malaria is a great concern for global health and accounts for a large amount of morbidity and
mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the …