Therapeutic strategies targeting the endothelial glycocalyx

DR Machin, M Sabouri, X Zheng… - Current Opinion in …, 2023 - journals.lww.com
We conclude that the glycocalyx is degraded in a variety of health conditions, although it
remains to be determined whether glycocalyx degradation plays a causal role in disease …

Placenta and maternal endothelium during preeclampsia: Disruption of the glycocalyx explains increased inositol phosphoglycans and angiogenic factors in maternal …

M Scioscia, M Siwetz, PY Robillard, A Brizzi… - Journal of Reproductive …, 2023 - Elsevier
The etiology of the pregnancy syndrome preeclampsia is still unclear, while most
hypotheses center on the placenta as the major contributor of the syndrome. Especially …

[HTML][HTML] Features and Comparative Characteristics of Fucosylated Glycans Expression in Endothelial Glycocalyx of Placental Terminal Villi in Patients with …

MM Ziganshina, GV Kulikova, KT Muminova… - International Journal of …, 2023 - mdpi.com
Antihypertensive therapy is an essential part of management of patients with preeclampsia
(PE). Methyldopa (Dopegyt®) and nifedipine (Cordaflex®) are basic medications of therapy …

Pathogenetic rationale for the ineffectiveness of antihypertensive therapy based on vasoactive status analysis in patients with early-onset preeclampsia

MM Ziganshina, KT Muminova… - Obstetrics and …, 2023 - journals.eco-vector.com
The central-acting antihypertensive drug Dopegyt and the calcium channel blocker
Cordaflex are commonly used in obstetric practice for managing hypertensive disorders …

Comparative analysis of the effect of two antihypertensive therapy regimens on maternal hemodynamic parameters in earlyand late-onset preeclampsia

KT Muminova, ZS Khodzhaeva… - Obstetrics and …, 2023 - pediatria.orscience.ru
Objective: To investigate the effect of antihypertensive therapy on maternal hemodynamic
profile and the relationship between hemodynamic parameters and endothelial glycocalyx …

Proteoglycans in mechanobiology of tissues and organs: Normal functions and mechanopathology

MC Farach‐Carson, D Wu… - Proteoglycan Research, 2024 - Wiley Online Library
Proteoglycans (PGs) are a diverse class of glycoconjugates that serve critical functions in
normal mechanobiology and mechanopathology. Both the protein cores and attached …

Paradigm shift in pharmacotherapy for late-onset preeclampsia: advantages of two-component antihypertensive therapy compared to monotherapy based on analysis …

MM Ziganshina, KT Muminova… - Obstetrics and …, 2023 - journals.eco-vector.com
An important aspect of the effectiveness of antihypertensive therapy is its effect on the
production of vasoactive factors that control blood pressure (BP). The most commonly used …