The accepted paradigm for both cellular and anti-tumor immunity relies upon tumor cell
killing by CD8+ T cells recognizing cognate antigens presented in the context of target cell …

A major problem with treating patients with cancer by traditional chemotherapeutic regimes
is that their tumors often develop a multidrug resistant (MDR) phenotype and subsequently …

We now know that tumor necrosis factor (TNF) family ligands regulate development of
lymphoid tissue and coordinate cellular differentiation to defend against intracellular …

For targets that are homogenously expressed, such as CD19 on cells of the B lymphocyte
lineage, immunotherapies can be highly effective. Targeting CD19 with blinatumomab, a …

CD8+ T cells appear to play an important pathophysiologic role in many inflammatory lung
diseases. The primary effector function of this T-cell subset is cytolysis of virus-infected cells …

Until now, it has been unclear whether murine cytomegalovirus (MCMV)-encoded protein
m144 directly regulates natural killer (NK) cell effector function and whether the effects of …

After hematopoietic stem cell transplantation, the persistence and expansion of grafted
mature postthymic T cells allow both transfer of donor immunologic memory and generation …

The role of Fas-mediated lysis of hepatocytes in hepatitis C virus (HCV)-induced injury is
frequently discussed. We therefore analyzed the effect of the number of HCV antigen …

CTL lyse target cells through the release of cytolytic granule mediators and expression of the
death receptor ligand Fas ligand (FasL). We previously demonstrated that FasL is stored in …

The immune system uses both virus-specific T cells and B cells to control the acute and
latent phases of respiratory infection with the murine gammaherpesvirus 68 (γHV-68). We …