Drug metabolism is a critical process for the removal of unwanted substances from the body.
In humans, approximately 80% of oxidative metabolism and almost 50% of the overall …

Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …

Small molecular tyrosine kinase inhibitors (smTKIs) are in the centre of the very quickly
expanding area of personalized chemotherapy and oral applicability thereof. The number of …

Five-and six-membered heteroaromatic rings and their benzo-fused homologues are well
established as important structural elements in drug design and are well represented in …

A prevalent feature of Strongyloides stercoralis is a life-long and potentially lethal infection
that is due to the nematode parasite's ability to autoinfect and, thereby, self-replicate within …

Colorectal cancer (CRC) represents the third leading cause of death among cancer patients
below the age of 50, necessitating improved treatment and prevention initiatives. A crude …

Understanding the potential for adverse drug reactions (ADRs), from herb-drug interactions,
is a key aspect of medicinal plant safety, with particular relevance for public health in …

Dibenzyl trisulfide (DTS) is the major active ingredient expressed in Petiveria alliacea L., a
shrub widely used for a range of conditions, such as, arthritis, asthma and cancer. Given its …

The effect of apocynin on the activity of arylamine N-acetyltransferases (NATs) in excised
liver samples was examined using eighteen Sprague-Dawley rats. Three groups of six …

Quassinoids often exhibit antioxidant and antiproliferative activity. Emerging evidence
suggests that these natural metabolites also display chemopreventive actions. In this study …