Drug-metabolizing cytochrome P450 enzymes have multifarious influences on treatment outcomes
Y Song, C Li, G Liu, R Liu, Y Chen, W Li, Z Cao… - Clinical …, 2021 - Springer
Drug metabolism is a critical process for the removal of unwanted substances from the body.
In humans, approximately 80% of oxidative metabolism and almost 50% of the overall …
In humans, approximately 80% of oxidative metabolism and almost 50% of the overall …
The pharmacology of the cytochrome P450 epoxygenase/soluble epoxide hydrolase axis in the vasculature and cardiovascular disease
I Fleming - Pharmacological reviews, 2014 - ASPET
Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …
Variability in bioavailability of small molecular tyrosine kinase inhibitors
M Herbrink, B Nuijen, JHM Schellens… - Cancer treatment reviews, 2015 - Elsevier
Small molecular tyrosine kinase inhibitors (smTKIs) are in the centre of the very quickly
expanding area of personalized chemotherapy and oral applicability thereof. The number of …
expanding area of personalized chemotherapy and oral applicability thereof. The number of …
A synopsis of the properties and applications of heteroaromatic rings in medicinal chemistry
NA Meanwell - Advances in Heterocyclic Chemistry, 2017 - Elsevier
Five-and six-membered heteroaromatic rings and their benzo-fused homologues are well
established as important structural elements in drug design and are well represented in …
established as important structural elements in drug design and are well represented in …
Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis
A prevalent feature of Strongyloides stercoralis is a life-long and potentially lethal infection
that is due to the nematode parasite's ability to autoinfect and, thereby, self-replicate within …
that is due to the nematode parasite's ability to autoinfect and, thereby, self-replicate within …
[HTML][HTML] Potential chemopreventive, anticancer and anti-inflammatory properties of a refined artocarpin-rich wood extract of Artocarpus heterophyllus Lam.
Colorectal cancer (CRC) represents the third leading cause of death among cancer patients
below the age of 50, necessitating improved treatment and prevention initiatives. A crude …
below the age of 50, necessitating improved treatment and prevention initiatives. A crude …
[HTML][HTML] Inhibition of Cytochrome P450 Activities by Extracts of Hyptis verticillata Jacq.: Assessment for Potential HERB-Drug Interactions
Understanding the potential for adverse drug reactions (ADRs), from herb-drug interactions,
is a key aspect of medicinal plant safety, with particular relevance for public health in …
is a key aspect of medicinal plant safety, with particular relevance for public health in …
Significant inhibitory impact of dibenzyl trisulfide and extracts of Petiveria alliacea on the activities of major drug-metabolizing enzymes in vitro: An assessment of the …
Dibenzyl trisulfide (DTS) is the major active ingredient expressed in Petiveria alliacea L., a
shrub widely used for a range of conditions, such as, arthritis, asthma and cancer. Given its …
shrub widely used for a range of conditions, such as, arthritis, asthma and cancer. Given its …
[HTML][HTML] Treatment of Rats with Apocynin Has Considerable Inhibitory Effects on Arylamine N-Acetyltransferase Activity in the Liver
The effect of apocynin on the activity of arylamine N-acetyltransferases (NATs) in excised
liver samples was examined using eighteen Sprague-Dawley rats. Three groups of six …
liver samples was examined using eighteen Sprague-Dawley rats. Three groups of six …
Glaucarubulone glucoside from Castela macrophylla suppresses MCF‐7 breast cancer cell growth and attenuates benzo[a]pyrene‐mediated CYP1A gene induction
SAM Badal, MM Asuncion Valenzuela… - Journal of Applied …, 2017 - Wiley Online Library
Quassinoids often exhibit antioxidant and antiproliferative activity. Emerging evidence
suggests that these natural metabolites also display chemopreventive actions. In this study …
suggests that these natural metabolites also display chemopreventive actions. In this study …