Nitrotyrosine, nitrated lipoproteins, and cardiovascular dysfunction in patients with type 2 diabetes: What do we know and what remains to be explained?

GK Jakubiak, G Cieślar, A Stanek - Antioxidants, 2022 - mdpi.com
Diabetes mellitus (DM) is a strong risk factor for the development of cardiovascular diseases
(CVDs), which are the most important cause of morbidity and mortality in the population of …

Atherosclerosis and its related laboratory biomarkers

V Della Corte, F Todaro, M Cataldi… - International Journal of …, 2023 - mdpi.com
Atherosclerosis constitutes a persistent inflammatory ailment, serving as the predominant
underlying condition for coronary artery disease (CAD), peripheral artery disease (PAD) …

Use of apolipoprotein B in the era of precision medicine: time for a paradigm change?

J Cole, R Zubirán, A Wolska, I Jialal… - Journal of Clinical …, 2023 - mdpi.com
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death
worldwide and the risk of a major cardiovascular event is highest among those with …

When nitrosative stress hits the endoplasmic reticulum: Possible implications in oxLDL/oxysterols-induced endothelial dysfunction

MG Nasoni, R Crinelli, L Iuliano, F Luchetti - Free Radical Biology and …, 2023 - Elsevier
Oxidized LDL (oxLDL) and oxysterols are known to play a crucial role in endothelial
dysfunction (ED) by inducing endoplasmic reticulum stress (ERS), inflammation, and …

Tackling dyslipidemia in obesity from a nanotechnology perspective

LM Trandafir, G Dodi, O Frasinariu, AC Luca… - Nutrients, 2022 - mdpi.com
Obesity and dyslipidemia are the main features of metabolic syndrome, expressed mainly by
adipose tissue dysfunction and connected by similar pathways and pharmacotherapy …

Ischemic heart disease in patients with inflammatory bowel disease: risk factors, mechanisms and prevention

AE Jucan, O Gavrilescu, M Dranga, IV Popa, BM Mihai… - Life, 2022 - mdpi.com
According to new research, a possible association between inflammatory bowel disease
(IBD) and an increased risk of ischemic heart disease (IHD) has been demonstrated, but this …

Might Gut Microbiota Be a Target for a Personalized Therapeutic Approach in Patients Affected by Atherosclerosis Disease?

MM Ciccone, ME Lepera, AI Guaricci, C Forleo… - Journal of Personalized …, 2023 - mdpi.com
In recent years, the increasing number of studies on the relationship between the gut
microbiota and atherosclerosis have led to significant interest in this subject. The gut …

Imipramine Treatment Alters Sphingomyelin, Cholesterol, and Glycerophospholipid Metabolism in Isolated Macrophage Lysosomes

JM Albright, MJ Sydor, J Shannahan, CR Ferreira… - Biomolecules, 2023 - mdpi.com
Lysosomes are degradative organelles that facilitate the removal and recycling of potentially
cytotoxic materials and mediate a variety of other cellular processes, such as nutrient …

Sex differences define the vulnerability to atherosclerosis

AV Poznyak, VN Sukhorukov, S Guo… - Clinical Medicine …, 2023 - journals.sagepub.com
For several decades, atherosclerosis has attracted the attention of researchers around the
world. Even being a major cause of serious cardiovascular disease and events …

RFX1 regulates foam cell formation and atherosclerosis by mediating CD36 expression

S Yang, X Min, L Hu, M Zheng, S Lu, M Zhao… - International …, 2024 - Elsevier
Background and aims Atherosclerosis (AS) is a continuously low-grade inflammatory
disease, and monocyte-derived macrophages play a vital role in AS pathogenesis …