Transporters are divided into the ABC and SLC super-families, mediating the cellular efflux
and influx of various xenobiotic and endogenous substrates. Here, an extensive literature …

Background Genetic polymorphisms are known to influence outcomes with phenytoin yet
effects in the Middle East and North Africa region are poorly understood. Objectives The …

Background: Increasing trend of breast cancer incidence worldwide is a known fact. This
curable disease may become fatal if drug resistance is developed leading to metastatic …

The goal of our study was to investigate the contribution of ABCB1 expression to the risk of
clopidogrel resistance (CR). Platelets functions were measured using the Verify-Now P2Y12 …

Background Compared with western countries, Asian breast cancer patients have unique
pathological and biological characteristics. Most of them are premenopausal women with …

Background Genetic polymorphisms of drug efflux transporters as ATP-binding cassette
subfamily B, member 1 (ABCB1) have been suggested to modulate antiepileptic drugs …

Background Breast cancer is the most common cause of cancer death among women.
Several studies have investigated the relationship between the C3435T polymorphism of …

Breast cancer (BC) is the most common cause of cancer-related death in women worldwide.
Several ABCB1 and VEGFA gene polymorphisms, such as ABCB1-G1199 T/A (rs2229109) …

Aim Breast cancer is the most common cancer and the second leading cause of cancer-
related deaths among women. Several genetic and environmental factors are known to be …

The multidrug resistance gene 1 (MDR1) encodes a membrane-bound phosphoglycoprotein
(P-gp). It functions as a transmembrane efflux pump for various structurally unrelated …