Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that include
a variety of forms and clinical phenotypes. This heterogeneity complicates the clinical and …

Chemical synapses provide a vital foundation for neuron-neuron communication and overall
brain function. By tethering closely apposed molecular machinery for presynaptic …

In humans, neuroligin-3 mutations are associated with autism, whereas in mice, the
corresponding mutations produce robust synaptic and behavioral changes. However …

Autism spectrum disorder (ASD) comprises a range of neurological conditions that affect
individuals' ability to communicate and interact with others. People with ASD often exhibit …

Autism spectrum disorders (ASDs) present unique challenges in the fields of genetics and
neurobiology because of the clinical and molecular heterogeneity underlying these …

Background The ability to capture and sequence large contiguous DNA fragments
represents a significant advancement towards the comprehensive characterization of …

Neurexins and neuroligins are synaptic cell adhesion molecules. Neurexins are primary
located on the presynaptic membrane, whereas neuroligins are strictly postsynaptic …

The X‐linked NLGN3 gene, encoding a postsynaptic cell adhesion molecule, was involved
in a nonsyndromic monogenic form of autism spectrum disorder (ASD) by the description of …

Autism is a heterogeneous behaviorally defined neurodevelopmental disorder. It is defined
by the presence of marked social deficits, specific language abnormalities, and stereotyped …

Neurodevelopmental disorders have a strong genetic component, but despite widespread
efforts, the specific genetic factors underlying these disorders remain undefined for a large …