Protein glycosylation and tumor microenvironment alterations driving cancer hallmarks
Decades of research have disclosed a plethora of alterations in protein glycosylation that
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …
decisively impact in all stages of disease and ultimately contribute to more aggressive cell …
Analytical and biochemical perspectives of protein O-GlcNAcylation
Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …
unique monosaccharide modification discovered in the early 1980s. With the technological …
Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family
Glycosylation of proteins is an essential process in all eukaryotes and a great diversity in
types of protein glycosylation exists in animals, plants and microorganisms. Mucin-type O …
types of protein glycosylation exists in animals, plants and microorganisms. Mucin-type O …
Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration
JZ Wang, YY Xia, I Grundke-Iqbal… - Journal of Alzheimer's …, 2013 - content.iospress.com
Microtubule associated protein tau is a phosphoprotein which potentially has 80
serine/threonine and 5 tyrosine phosphorylation sites. Normal brain tau contains 2-3 moles …
serine/threonine and 5 tyrosine phosphorylation sites. Normal brain tau contains 2-3 moles …
Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease
O-GlcNAcylation is the addition of β-DN-acetylglucosamine to serine or threonine residues
of nuclear and cytoplasmic proteins. O-linked N-acetylglucosamine (O-GlcNAc) was not …
of nuclear and cytoplasmic proteins. O-linked N-acetylglucosamine (O-GlcNAc) was not …
O-GlcNAc profiling: from proteins to proteomes
Abstract O-linked β-DN-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) onto
serine and threonine residues of proteins is an important post-translational modification …
serine and threonine residues of proteins is an important post-translational modification …
[HTML][HTML] O-GlcNAc regulates pluripotency and reprogramming by directly acting on core components of the pluripotency network
Summary O-linked-N-acetylglucosamine (O-GlcNAc) has emerged as a critical regulator of
diverse cellular processes, but its role in embryonic stem cells (ESCs) and pluripotency has …
diverse cellular processes, but its role in embryonic stem cells (ESCs) and pluripotency has …
Protein O-GlcNAcylation in diabetes and diabetic complications
The post-translational modification of serine and threonine residues of proteins by O-linked
β-N-acetylglucosamine (O-GlcNAc) is highly ubiquitous, dynamic and inducible. Protein O …
β-N-acetylglucosamine (O-GlcNAc) is highly ubiquitous, dynamic and inducible. Protein O …
Glucosamine improves survival in a mouse model of sepsis and attenuates sepsis-induced lung injury and inflammation
JS Hwang, KH Kim, J Park, SM Kim, H Cho… - Journal of Biological …, 2019 - ASBMB
The aim of the current study was to investigate the effects of glucosamine (GlcN) on septic
lethality and sepsis-induced inflammation using animal models of mice and zebrafish. GlcN …
lethality and sepsis-induced inflammation using animal models of mice and zebrafish. GlcN …