A defining hallmark of glioblastoma is altered tumor metabolism. The metabolic shift towards
aerobic glycolysis with reprogramming of mitochondrial oxidative phosphorylation …

Angiogenesis is an important mediator of tumor progression. As tumors expand, diffusion
distances from the existing vascular supply increases resulting in hypoxia. Sustained …

Exosomes are emerging as important elements that participate in intercellular
communication and tumor microenvironment modulation, but the exact mechanisms by …

Exosomes participate in intercellular communication and glioma microenvironment
modulation, but the exact mechanisms by which glioma-derived exosomes (GDEs) promote …

Glioblastoma (GBM) is a highly malignant, rapidly progressive astrocytoma that is
distinguished pathologically from lower grade tumors by necrosis and microvascular …

Adaptation to hypoxia is mediated through a coordinated transcriptional response driven
largely by hypoxia-inducible factor 1 (HIF-1). We used ChIP-chip and gene expression …

Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common and
lethal primary brain tumor in adults; few treatments are available. Median survival rates …

Despite advances in surgical and medical therapy, glioblastoma consistently remains a fatal
disease. Over the last 20 years, no significant increase in survival has been achieved for …

Hypoxia is implicated in many aspects of tumor development, angiogenesis, and growth in
many different tumors. Brain tumors, particularly the highly aggressive glioblastoma …

We investigated whether increasing levels of tissue hypoxia, measured by the binding of
EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2, 2, 3, 3, 3-pentafluoropropyl) acetamide] or by …