Cancer is commonly thought to be the product of irregular cell division. According to the
World Health Organization (WHO), cancer is the major cause of death globally. Nature offers …

Simple Summary All cells within tissues and organ systems must communicate with each
other to ensure they function in a coordinated manner. One form of communication is …

Recent studies have furthered our understanding of the function of long noncoding RNAs
(lncRNAs) in numerous biological processes, including cancer. This study investigated the …

DNA double-strand break (DSB) repair is initiated by MRE11 nuclease for both homology-
directed repair (HDR) and alternative end joining (Alt-EJ). Here, we found that GRB2, crucial …

PEAK pseudokinases regulate cell migration, invasion and proliferation by recruiting key
signaling proteins to the cytoskeleton. Despite lacking catalytic activity, alteration in their …

Growth factor receptor-bound protein 2 (GRB2) is a cytoplasmic adapter for tyrosine kinase
signaling and a nuclear adapter for homology-directed-DNA repair. Here we find nuclear …

Objectives Lung cancer is still a disease with high morbidity and mortality in the world. Micro
RNA s have been proven to act as an indispensable role in the reuse of multiple solid …

Cellular heterogeneity is pervasive and of paramount importance in biology. Single-cell
analysis techniques are indispensable for understanding the heterogeneity and functions of …

Background: Growth factor receptor-bound protein 2 (Grb2) is a 25 kDa adaptor protein,
which was originally discovered to accomplish basic cellular events such as cell growth, cell …

GRB2 is an adaptor protein of HER2 (and several other tyrosine kinases), which we
identified as a novel BECN1 (Beclin 1) interacting partner. GRB2 co-immunoprecipitated …