There is increasing interest among functional neurosurgeons in the potential for novel
therapies to impact upon diseases beyond movement disorders and pain. A target of …

The increasing worldwide prevalence of obesity is partially related to the ready availability of
highly palatable foods which increases the incidence of hedonic, non-homeostatic feeding …

Cocaine craving, seeking, and relapse are mediated, in part, by cocaine-induced adaptive
changes in the brain reward circuits. The nucleus accumbens (NAc) integrates and …

Body weight is determined by a balance between food intake and energy expenditure.
Multiple neural circuits in the brain have evolved to process information about food, food …

A psychobiological dimension of eating behaviour is proposed, which is anchored at the low
end by energy intake that is relatively well matched to energy output and is reflected by a …

Antipsychotic drugs (APDs) represent a cornerstone in the treatment of schizophrenia and
other psychoses. The effectiveness of the first generation (typical) APDs are hampered by so …

A growing body of evidence suggests that nucleus accumbens (NAc) plays a significant role
not only in the physiological processes associated with reward and satisfaction but also in …

Ventral tegmental area dopamine neurons control reward-driven learning, and their
dysregulation can lead to psychiatric disorders. Tonic and phasic activity of these …

Positron emission tomography (PET) provides a means of studying physiological and
pharmacological processes as they occur in the living brain. Mice, rats, dogs, cats, pigs and …

Parkinson's disease (PD) is a neurodegenerative condition characterized by the loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) in the midbrain …