Xanthine oxidoreductase (XOR) consists of two different forms, xanthine dehydrogenase
and xanthine oxidase (XO), and is a rate-limiting enzyme of uric acid production from …

Serum uric acid (SUA) is significantly elevated in obesity, gout, type 2 diabetes mellitus, and
the metabolic syndrome and appears to contribute to the renal, cardiovascular and …

Despite the enhanced knowledge of the pathophysiology of heart failure (HF), it still remains
a serious syndrome with substantial morbidity, mortality, and frequent hospitalizations …

Cardiovascular diseases (CVD) are the leading cause of global mortality and their
pathogenesis lies mainly in the atherosclerotic process. There are close connections linking …

Aims Blood uric acid (UA) levels are frequently elevated in patients with heart failure and
reduced ejection fraction (HFrEF), may lead to gout and are associated with worse …

Objective: To assess the prognostic cut-off values of serum uric acid (SUA) in predicting fatal
and morbid heart failure in a large Italian cohort in the frame of the Working Group on Uric …

Background: Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the formation of
uric acid from hypoxanthine and xanthine, leading to an increase in superoxide and reactive …

Accumulating evidence suggests that high serum uric acid (UA) is associated with left
ventricular (LV) dysfunction. Although xanthine oxidase (XO) activation is a critical regulatory …

Uric acid, the metabolic mediator of gout and urate renal stones, is associated with
increased cardiovascular risk burden. Hyperuricemia is an old emerging metabolic disorder …

Aims Exercise intolerance in patients with heart failure (HF) is partly attributed to skeletal
muscle abnormalities. We have shown that reactive oxygen species (ROS) play a crucial …