iPSCs in neurodegenerative disorders: A unique platform for clinical research and personalized medicine

S Pandey, M Jirásko, J Lochman, A Chvátal… - Journal of personalized …, 2022 - mdpi.com
In the past, several animal disease models were developed to study the molecular
mechanism of neurological diseases and discover new therapies, but the lack of equivalent …

[HTML][HTML] Stem cell therapy for central nervous system disorders: Metabolic interactions between transplanted cells and local microenvironments

SA Sakowski, KS Chen - Neurobiology of disease, 2022 - Elsevier
Stem cell therapy is a promising and rapidly advancing treatment strategy for a multitude of
neurologic disorders. Yet, while early phase clinical trials are being pursued in many …

A systematic review and in silico analysis of studies investigating the ischaemic penumbra proteome in animal models of experimental stroke

JV Moxon, C Pretorius, AF Trollope… - Journal of Cerebral …, 2024 - journals.sagepub.com
Ischaemic stroke results in the formation of a cerebral infarction bordered by an ischaemic
penumbra. Characterising the proteins within the ischaemic penumbra may identify neuro …

Proteomic advance of ischemic stroke: preclinical, clinical, and intervention

T Zhao, J Zeng, R Zhang, L Pu, H Wang, L Pan… - Metabolic Brain …, 2023 - Springer
Ischemic stroke (IS) is the most common type of stroke and is characterized by high rates of
mortality and long-term injury. The prediction and early diagnosis of IS are therefore crucial …

Induced Pluripotent Stem Cells and Organoids in Advancing Neuropathology Research and Therapies

DB Pazzin, TTR Previato, JI Budelon Gonçalves… - Cells, 2024 - mdpi.com
This review delves into the groundbreaking impact of induced pluripotent stem cells (iPSCs)
and three-dimensional organoid models in propelling forward neuropathology research …

The advantages of multi-level omics research on stem cell-based therapies for ischemic stroke

Y Wang, C Chang, R Wang, X Li… - Neural Regeneration …, 2024 - journals.lww.com
Stem cell transplantation is a potential therapeutic strategy for ischemic stroke. However,
despite many years of preclinical research, the application of stem cells is still limited to the …

Research progress of stem cell therapy for ischemic stroke

T Li, GH Zhu - Ibrain, 2021 - Wiley Online Library
Ischemic stroke is a serious cerebrovascular disease with high morbidity, disability and
mortality. There is no doubt that the disease has a severe impact on the physical and mental …

干细胞治疗缺血性脑卒中多层组学研究的优势

Y Wang, C Chang, R Wang, X Li, X Bao - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
干细胞移植疗法是治疗缺血性脑卒中的潜在方法之一. 尽管已进行多年的临床前研究,
但干细胞在临床环境中的应用仍在探索中. 尽管干细胞在促进缺血性脑卒中功能恢复方面具有 …

iPSCs and Organoids in Advancing Neuropathology Research and Therapies

DB Pazzin, T Previato, JIB Gonçalves, G Zanirati… - 2024 - preprints.org
This review explores the transformative role of induced pluripotent stem cells (iPSCs) and
organoids in advancing neuropathology research. Focused on Alzheimer's disease …