Microfluidic chips are valuable tools for studying intricate cellular and cell–microenvironment
interactions. Traditional in vitro cancer models lack accuracy in mimicking the complexities …

Some relevant emerging properties of intelligent systems are “adaptation to a changing
environment,”“reaction to unexpected situations,”“capacity of problem solving,” and “ability to …

We propose an original strategy for metastasis prevention using a combination of three
microRNAs that blocks the dedifferentiation of cancer cells in a metastatic niche owing to the …

In this study, we examined the metabolic adaptations of a chemoresistant prostate cancer
cell line in comparison to a sensitive cell line. We utilized prostate cancer LNCaP cells and …

The ability of tumors to survive therapy reflects both cell-intrinsic and microenvironmental
mechanisms. Across many cancers, including triple-negative breast cancer (TNBC), a high …

Background Several cytotoxic chemotherapies have demonstrated efficacy in improving
recurrence‐free survival (RFS) following resection of Stage II–IV colorectal cancer (CRC) …

Abstract The von Hippel-Lindau protein (pVHL) is a tumor suppressor involved in oxygen
regulation via dynamic nucleocytoplasmic shuttling. It plays a crucial role in cell survival by …

Uveal melanoma (UM) is the most common primary ocular tumor in the adult population.
Even though these primary tumors are successfully treated in 90% of cases, almost 50% of …

Cancer is a profoundly dynamic, heterogeneous and aggressive systemic ailment, with a
coordinated evolution of various types of tumor niches. Hypoxia plays an indispensable role …

Tumor recurrence is a mechanism triggered in sparse populations of cancer cells that
usually remain in a quiescent state after strict stress and/or therapeutic factors, which is …