An update on the regulatory mechanisms of NLRP3 inflammasome activation
Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
PANoptosis: a unique innate immune inflammatory cell death modality
N Pandian, TD Kanneganti - The Journal of Immunology, 2022 - journals.aai.org
Innate immunity is the first response to protect against pathogens and cellular insults.
Pattern recognition receptors sense pathogen-and damage-associated molecular patterns …
Pattern recognition receptors sense pathogen-and damage-associated molecular patterns …
ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis
Cell death provides host defense and maintains homeostasis. Zα-containing molecules are
essential for these processes. Z-DNA binding protein 1 (ZBP1) activates inflammatory cell …
essential for these processes. Z-DNA binding protein 1 (ZBP1) activates inflammatory cell …
Programming inflammatory cell death for therapy
S Christgen, RE Tweedell, TD Kanneganti - Pharmacology & therapeutics, 2022 - Elsevier
Programmed cell death (PCD) is an essential part of organismal development and plays
fundamental roles in host defense against pathogens and the maintenance of homeostasis …
fundamental roles in host defense against pathogens and the maintenance of homeostasis …
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
KV Swanson, M Deng, JPY Ting - Nature Reviews Immunology, 2019 - nature.com
Abstract NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) is an intracellular
sensor that detects a broad range of microbial motifs, endogenous danger signals and …
sensor that detects a broad range of microbial motifs, endogenous danger signals and …
The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)
M Zheng, TD Kanneganti - Immunological reviews, 2020 - Wiley Online Library
ZBP1 has been characterized as a critical innate immune sensor of not only viral RNA
products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced …
products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced …
[HTML][HTML] Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes
COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute
lung damage associated with patient mortality. While multiple inflammatory cytokines are …
lung damage associated with patient mortality. While multiple inflammatory cytokines are …
[HTML][HTML] Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the
exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic …
exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic …
Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses
H Feng, YB Zhang, JF Gui, SM Lemon… - PLoS …, 2021 - journals.plos.org
The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally
identified as a nuclear factor that binds and activates the promoters of type I interferon …
identified as a nuclear factor that binds and activates the promoters of type I interferon …
Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice
J Zeng, X Xie, XL Feng, L Xu, JB Han, D Yu, QC Zou… - …, 2022 - thelancet.com
Summary Background The Coronavirus Disease 2019 (COVID-19) pandemic has been a
great threat to global public health since 2020. Although the advance on vaccine …
great threat to global public health since 2020. Although the advance on vaccine …