BACKGROUND Trophectoderm (TE) biopsy and next generation sequencing (NGS) are
currently the preferred techniques for preimplantation genetic testing for aneuploidies (PGT …

There is a high incidence of chromosomal abnormalities in early human embryos, whether
they are generated by natural conception or by assisted reproductive technologies (ART) …

Objective To accurately determine mitochondrial DNA (mtDNA) levels in human blastocysts.
Design Retrospective analysis. Setting IVF clinic. Patient (s) A total of 1,396 embryos derived …

A substantial proportion of tumors consist of genotypically distinct subpopulations of cancer
cells. This intratumor genetic heterogeneity poses a substantial challenge for the …

Preimplantation genetic testing (PGT) has evolved into a well-established alternative to
invasive prenatal diagnosis, even though genetic testing of single or few cells is quite …

STUDY QUESTION What is the accuracy of preimplantation genetic testing for aneuploidies
(PGT-A) when considering human peri-implantation outcomes in vitro? STUDY ANSWER …

Objective To assess whether embryonic DNA isolated from blastocyst culture conditioned
medium (BCCM) combined with blastocoel fluid (BF) could be used for blastocyst stage non …

Designed to minimize chances of transferring genetically abnormal embryos,
preimplantation genetic diagnosis (PGD) involves in vitro fertilization (IVF), embryo biopsy …

Sequencing of a single-cell genome requires DNA amplification, a process prone to
introducing bias and errors into the amplified genome. Here we introduce a novel multiple …

Whole genome amplification (WGA) is a technology for non‐selective amplification of the
whole genome sequence, first appearing in 1992. Its primary purpose is to amplify and …