Although it was originally believed that thyroid hormones enter target cells by passive
diffusion, it is now clear that cellular uptake is effected by carrier-mediated processes. Two …

Kinetic tracer studies show that thyroid hormones are transported into target tissues by
stereospecific, high-affinity, low-capacity transporters, both in animals and humans. The Kd …

While it is well known that sepsis inhibits serum IGF-I and its gene expression in the liver, the
effect on pituitary GH and IGF-binding protein-3 (IGFBP-3) is poorly understood. The GH-IGF …

New research is demonstrating that thyroid hormone transport across cellular membranes
plays an important role in intracellular triiodothyronine (T3) levels of peripheral and pituitary …

The proliferation of normal human breast epithelial cells in women is highest during the first
trimester of pregnancy. In an attempt to analyze this hormonal environment in a model …

The effects of 48-h fasting on transport of T3 and subsequent metabolism in the isolated
perfused rat liver were investigated. Tracer T3 disappearance curves from the recirculating …

Assesses the significance of plasma membrane transport in the bioavailability of thyroid
hormone. Specificity of thyroid hormone plasma membrane transport; Requirements for …

We have previously shown that human skin fibroblasts exposed to preformed low density
lipoprotein (LDL)-thyroxine (T4) complexes internalize more T4 than they do when exposed …

Recently, we described a two-pool model for 3, 5, 3'-triiodothyronine uptake and metabolism
in the isolated perfused rat liver. Here, we applied this model to investigate transmembrane …

Investigation of suspected hyperthyroidism is conventionally based on measurement of total
or free T 4 as the initial test, followed in equivocal cases by total or free T 3, and the TRH …