Executive summary Despite substantial progress in reducing the global impact of many non-
communicable diseases, including heart disease and cancer, morbidity and mortality due to …

Short telomeres confer risk of degenerative diseases. Chronic psychological stress can lead
to disease through many pathways, and research from in vitro studies to human longitudinal …

Many physiological changes occur with aging. These changes often, directly or indirectly,
result in a deterioration of the quality of life and even in a shortening of life expectancy …

Ageing is the predominant risk factor for many common diseases. Human premature ageing
diseases are powerful model systems to identify and characterize cellular mechanisms that …

Research on mechanisms underlying fetal programming of health and disease risk has
focused primarily on processes that are specific to cell types, organs or phenotypes of …

Telomere length measurement is increasingly recognized as a clinical gauge for age-related
disease risk. There are several methods for studying blood telomere length (BTL) as a …

The principal objective was to determine the extent to which physical activity (PA) accounts
for differences in leukocyte telomere length (LTL) in a large random sample of US adults …

Transformed cells must acquire specific characteristics to be malignant. Weinberg and
Hanahan characterize these characteristics as cancer hallmarks. Though these features are …

Major depressive disorder (MDD) is highly prevalent in adolescents and is a major risk factor
for suicidality. Recent evidence shows that accelerated cellular senescence/aging is …

Age-related decline in immunity is characterized by stem cell exhaustion, telomere
shortening, and disruption of cell-to-cell communication, leading to increased patient risk of …